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Tyrosine kinase

IGF binding proteins -

FIGURE 5-27 Somatomedins appear to mediate somatic cell growth. Abbreviations: NSILAs, nonsuppressible insulin-like activities; SM, somatomedin. These factors are now generally referred to as insulin-like growth factors (IGFs). Growth hormone is released from the somatotroph of the anterior pituitary whose regulation is suggested in this figure. After binding to the hepatocyte (in this illustration) GH receptor, reactions follow in the cell that stimulate the release of somatomedins, e.g., SM-C = IGF-I. IGFs bind to their receptors (one shown here) and tyrosine kinase activity is stimulated (this enzyme may be part of the receptor). It is hypothesized that a specific protein may be phosphorylated whose action directly or indirectly results in a growth response.

(IGF-ll and insulin can act as weak ligands in absence of IGF-I)

FIGURE 5-27 Somatomedins appear to mediate somatic cell growth. Abbreviations: NSILAs, nonsuppressible insulin-like activities; SM, somatomedin. These factors are now generally referred to as insulin-like growth factors (IGFs). Growth hormone is released from the somatotroph of the anterior pituitary whose regulation is suggested in this figure. After binding to the hepatocyte (in this illustration) GH receptor, reactions follow in the cell that stimulate the release of somatomedins, e.g., SM-C = IGF-I. IGFs bind to their receptors (one shown here) and tyrosine kinase activity is stimulated (this enzyme may be part of the receptor). It is hypothesized that a specific protein may be phosphorylated whose action directly or indirectly results in a growth response.

5. Anterior Pituitary Hormones hlGF-1

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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