M

iSee text 1 and [ Figure 5-21J

Promotes proliferation of B cells Promotes proliferation of B cells

Promotes proliferation of B-cell progenitors Activates macrophages Enhances most cell growth Inhibits clonal expansion of T cells

" The information in this table was adapted from two sources: Metcalf, D., Nicola, N., and Gough, N. M. (1995). Hormone and blood cell production. In "Endocrinology" (L. J. DeGroot et al, eds.), Vol. 3, pp. 2943-2963. W.B. Saunders, Philadelphia, PA; and Rang, H. P., Dale, M. M., Ritter, J. M., and Gardner, P. (1995). "Pharmacology," p. 242. Churchill-Livingston, New York. Abbreviations employed are as follows: PSC, pluripotent stem cells; G, granulocyte; M, macrophage; E, eosinophils; Ey, erythroid cells; Meg, megakarocytes; MC, mast cells; T, T lymphocytes; B, B lymphocytes; NK, natural killer cells.

h IL-1 is produced as a consequence of infection or antigenic challenge. It produces a wide array of effects in the immune responses and induces other cytokines.

c IL-2 stimulates proliferation and maturation of TW2 cells and production by T1/2 cells of cell cytokines that control the differentiation and proliferation of B cells.

d IL-3 acts on the pluripotent hematopoietic stem cell to promote the development of G, M, F, Ey, Meg, and MC.

eIL-6 activates stromal bone marrow cells to produce colony-stimulating factors and acts as a pyrogen (i.e., raises body temperature; promotes proliferation of B and T cells).

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