Info

Cortisol

<0.0001

Aldosterone

<0.0001

" The relative competitive index (RCI) is a measure of the ability of a given ligand to compete with [3H]dihydrotestosterone (DHT). The RCI for DHT is set to 100%. Data were abstracted from Hiipakka, R. A., and Liao, S. (1995). Androgen physiology. In "Endocrinology" (L. J. DeGroot, M. Besser, H. G. Burger, J. L. Jameson, D. L. Loriaux, J. C. Marshall, W. D. Odell, J. T. Potts, Jr., and A. H. Rubenstein, eds.), 3rd ed., Vol. 3, pp. 2336-2350. W. B. Saunders Company, Philadelphia, PA.

" The relative competitive index (RCI) is a measure of the ability of a given ligand to compete with [3H]dihydrotestosterone (DHT). The RCI for DHT is set to 100%. Data were abstracted from Hiipakka, R. A., and Liao, S. (1995). Androgen physiology. In "Endocrinology" (L. J. DeGroot, M. Besser, H. G. Burger, J. L. Jameson, D. L. Loriaux, J. C. Marshall, W. D. Odell, J. T. Potts, Jr., and A. H. Rubenstein, eds.), 3rd ed., Vol. 3, pp. 2336-2350. W. B. Saunders Company, Philadelphia, PA.

one) in its target cells, translocates to the nucleus of the cell where it functions as a ligand-activated transcriptional regulatory protein. A general discussion of this model for steroid hormone action is presented in Figure 1-41.

A wide variety of genes have been shown to be regulated by androgens and the AR; this is consistent with the phenotypic differences of females and males. Table 12-6 tabulates the long list of target organs that possess the AR.

TABLE 12-8 Summary of Androgen Receptor Mutations Associated with Androgen-Insensitivity Syndrome (AIS)"

Structural defects (~8%)

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