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T. 100 nmole r T3 42 nmole figure 6-12 Daily production of T3, T4, and rT3 in normal human subjects. [Modified from Pittman, C. S. (1979). Hormone metabolism. In "Endocrinology" (L. J. DeGroot, G. F. Cahill, L. Martini, D. H. Nelson, W. D. Odell, J. T. Potts, E. Steinberger, and A. I. Winegrad, eds.), Vol. 1, p. 365. Grune & Stratton, New York.]

T. 100 nmole r T3 42 nmole figure 6-12 Daily production of T3, T4, and rT3 in normal human subjects. [Modified from Pittman, C. S. (1979). Hormone metabolism. In "Endocrinology" (L. J. DeGroot, G. F. Cahill, L. Martini, D. H. Nelson, W. D. Odell, J. T. Potts, E. Steinberger, and A. I. Winegrad, eds.), Vol. 1, p. 365. Grune & Stratton, New York.]

olism. In the liver, stepwise deiodination is the prime pathway for inactivation (Figure 6-13A). Other transformations that have been detected include /3-glucuronide and sulfate conjugation with the phenol functionality and transamination or deamination of the alanine side chain (Figure 6-13B).

G. Antithyroid Drugs

Specific compounds that interfere with the thyroid follicular peroxidase are used both in research and in certain clinical circumstances. In general, small doses of goitrogens preferentially block the coupling reactions in the thyroid, while large doses block the iodin-ation of the tyrosyl residues in thyroglobulin. The most potent antithyroid compounds contain the thionamide group (see Figure 6-14). The simplest member of the group is thiourea; the compounds thiouracil and 6-n-propylthiouracil are significantly more potent. The structures of several antithyroid drugs are given in Figure 6-15.

Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

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