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IV XIX XVII XXIA XXIB aro c17 c21A c21B

? XIA XIB Cl c11 scc

FIGURE 2-31 Evolutionary relationship of P450 genes. The vertical scale describes evolutionary time in millions of years. The Roman numerals refer to the standardized nomenclature employed for P450 gene families (see Nebert et al., 1987). The question mark suggests the probable existence of other mitochondrial families of P450 such as those required for vitamin D metabolism and bile acid hydroxylation (see Table 2-6). Adapted from Figure 7 of Miller, W. (1988). Molecular biology of steroid hormone biosynthesis. Endocr. Rev. 9, 295-318.

IV XIX XVII XXIA XXIB aro c17 c21A c21B

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