Skin of frog Bombina bombina Amphibian skin Amphibian skin Amphibian skin Mammalian gut and brain GI tract, pancreas, CNS

Amphibian skin Amphibian skin

Hypothalamus Brain

Stimulate gastrin release and gallbladder contraction Similar to bombesin Similar to bombesin Similar to bombesin

Stimulation of gastrin release from antral G cells Stimulates gastrin release; in hypothalamus inhibits TS-11 release

Mimics CCK actions to stimulate gallbladder contractions

Nociception; pain pathway vasodilation Smooth muscle contraction, vasodilation Smooth muscle contraction

" The information in this table was abstracted from Wilding, J. P. H., Ghatei, M. A., and Bloom, S. R. (1995). Hormones of the Gastrointestinal tract. In "Endocrinology" (L. J. DeGroot, M. Besser, H. G. Burger, J. L. Jameson, D. L. Loriaux, J. C. Marshall, W. D. Odell, J. T. Potts, Jr., and A. H. Rubenstein, eds.), Vol. 3, Chapter 153, pp. 2870-2894. W. B. Saunders, Philadelphia, PA; and from (1995) Peptides as mediators. In "Pharmacology" (H. P. Rang, M. M. Dale, J. M. Ritter, and P. Gardner, eds.), Chapter 9, pp. 191-202. Churchill-Livingstone, New York.


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