" The information in this table was abstracted from Wilding, J. P. H., Ghatei, M. A., and Bloom, S. R. (1995). Hormones of the Gastrointestinal tract. In "Endocrinology" (L. J. DeGroot, M. Besser, H. G. Burger, J. L. Jameson, D. L. Loriaux, J. C. Marshall, W. D. Odell, J. T. Potts, Jr., and A. H. Rubenstein, eds.), Vol. 3, Chapter 153, pp. 2870-2894. W. B. Saunders, Philadelphia, PA.

VIP is present in a large number of neurons within the gut, CNS, and urogenital tract. The biological actions of VIP, which are largely mediated in a paracrine fashion, are summarized in Table 8-9.

The biological actions of VIP are mediated via interaction with an outer cell membrane receptor that has seven transmembrane domains and significant homology with the secretin receptors. The VIP receptor is believed to be coupled to adenylate cyclase.

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