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Epithelial cells

ep3

ep2

" Receptor types commonly found in each cell type or, in parentheses, found only in those from particular species. This table is reproduced by permission from Coleman, R. A., and Humphrey, P. P. A. (1993). Prostanoid receptors: Their function and classification. In: "Therapeutic Applications of Prostaglandins" 0.R. Vane and J. O'Grady, eds.), p. 21. Edward Arnold, London.

h Contraction of smooth muscle and myofibroblasts, activation of inflammatory cells to release mediators, depolarization of neurons, aggregation of platelets, luteolysis of the corpus luteum, and secretion from epithelial cells.

c Relaxation of smooth muscle, inhibition of mediator release from inflammatory cells, hyperpolarization of neurons, inhibition of aggregation by platelets, Iysolysis by adipocytes, and secretion by epithelial cells.

" Receptor types commonly found in each cell type or, in parentheses, found only in those from particular species. This table is reproduced by permission from Coleman, R. A., and Humphrey, P. P. A. (1993). Prostanoid receptors: Their function and classification. In: "Therapeutic Applications of Prostaglandins" 0.R. Vane and J. O'Grady, eds.), p. 21. Edward Arnold, London.

h Contraction of smooth muscle and myofibroblasts, activation of inflammatory cells to release mediators, depolarization of neurons, aggregation of platelets, luteolysis of the corpus luteum, and secretion from epithelial cells.

c Relaxation of smooth muscle, inhibition of mediator release from inflammatory cells, hyperpolarization of neurons, inhibition of aggregation by platelets, Iysolysis by adipocytes, and secretion by epithelial cells.

lasting bronchoconstriction and is extremely potent. SRS-A has been shown to be formed by the incorporation of radiolabeled arachidonate and 35S. SRS compounds have been characterized as LTs (see Figure 16-11). LTA, LTB, and LTC were isolated from a murine mastocytoma cell line and from rabbit polymorphonuclear leukocytes. LTs are derivatives of arachidonic acid or eicosapentaenoic acid, and many contain glutathione or cysteine.

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