figure 7-25 Dose-response curves of glucose suppression of glucagon release stimulated by amino acids and of glucose stimulation of insulin secretion as obtained by studies in vitro with the isolated perfused pancreas of the rat. [Modified from Matschinsky, F. M., Pagliara, A. A., Zawalich, W. S., and Trus, M. D. (1979). Metabolism of pancreatic islets and regulation of insulin and glucagon. In "Endocrinology" (L. ]. DeGroot et al., eds.), Vol. 2, p. 937. Grune & Stratton, New York.]

ble the inhibition of lipolysis without an associated fall in glucose. A key unresolved issue concerns the detailed role of somatostatin in pancreatic islet functioning. Although somatostatin is known to inhibit the secretion of both insulin and glucagon, the molecular basis and physiological rationale for this effect are not clear.

fallen off since the report in 1971 that persons treated with tolbutamide for 8 years had a higher death rate from cardiovascular disease than did control subjects.

The biological mechanism of action of the sulfonylurea agents is believed to be dependent upon their

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B exercise _^glucagon i insulin

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