Hormones of the Adrenal Medulla I. Introduction 319

II. Anatomical, Morphological, and Physiological Relationships 320

A. Introduction 320

B Development of the Adrenal Medulla 320 C Autonomic Nervous System and the

Adrenal Medulla 320 D Histology of the Adrenal Medulla 320

III. Chemistry 321

IV. Hormone Action and Biochemistry 323

A Biochemistrv of the Chromaffin Cell of the

Adrenal Medulla 323 B Regulation of Biosynthesis 325 C Content of Neurosecretory Granules and Secretion 326 D. Catabolism of Catecholamines 327 V. Actions of Epinephrine 328

A. General Effects of Catecholamines 328 B Effects of Epinephrine on Glycogenosis in the Liver 331

C. Ugand Detection of the Adrenergic Receptor Subclasses 335

D. Regulation of Adrenergic Reccptors 335 VI. Enkephalins 337

VII. Clinical Aspects 338 References 339

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