Info

Lanosterol (59)

FIGURE 2-15 Proposed mechanism for the cyclization of 2,3-oxidosqualene (57) to produce lanosterol (59). This mechanism is postulated from model organic reactions.

biosynthesis of cholesterol, particularly in hypercholesterolemia, a familial disorder of lipid metabolism.

Sodium 2-phenylbutyrate (62) and sodium (p-chloro-phenox)isobutyrate (or Clofibrate) (63) are both aryl-substituted short chain fatty acids that interfere with the acylation of coenzyme A and block the initiation of cholesterol synthesis. Benzmalacene (64) blocks sterol synthesis somewhere between isopentenyl pyrophosphate and farnesyl pyrophosphate. Analogs of tris[2-

(diethylamino)ethyl]phosphate trihydrochloride, such as SKF-7997 (65), effectively block the cyclization of the 2,3-epoxide of squalene. Both MER-29 (66) and 22,25-diazacholestanol (67) block the reduction of desmosterol to cholesterol, while AY-9944 (68) blocks the conversion of 7-dehydrocholesterol to cholesterol. Lovastatin (69) has been approved by the FDA for use as a serum cholesterol-lowering agent; it acts as an inhibitor of HMG-CoA reductase.

Lower Your Cholesterol In Just 33 Days

Lower Your Cholesterol In Just 33 Days

Discover secrets, myths, truths, lies and strategies for dealing effectively with cholesterol, now and forever! Uncover techniques, remedies and alternative for lowering your cholesterol quickly and significantly in just ONE MONTH! Find insights into the screenings, meanings and numbers involved in lowering cholesterol and the implications, consideration it has for your lifestyle and future!

Get My Free Ebook


Post a comment