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I-Gly

Oxytocin |

- Neurcphysin I "

Prepro - Oxytocin

FIGURE 4-6 Preprovasopressin and preprooxytocin. Proteolytic maturation proceeds from top to bottom for each precursor. The organization of the gene translation products is similar in either case, except that a glycoprotein is included in the proprotein of VP in the C-terminal region. Heavily stippled bars of the NPs represent conserved amino acid regions; lightly stippled bars represent variable C- and N-termini. VP and OT are expressed as polyproteins. Reproduced from Richter, D. (1983). Trends Biochem. Sci. 8,278-281.

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