Topoisomerase cleavage site

Protein kinase responsive region

FIGURE 5-16 (A) Processing of the human prolactin gene. The exons are denoted by numbers (1-5) and the introns by letters (A-D). (B) Detailed analysis of the 5' flanking regions of the rat prolactin gene. Abbreviations: ERE, estrogen response element; TRE, thyroid response element; IP, 2P, 3P, and 4P refer to proximal binding sites for Pit-1; ID, 2D, 3D, and 4D refer to distal binding sites for Pit-1. Reproduced with permission from Molitch, M. E. (1995). Prolactin. In "The Pituitary" (S. Melmed, ed.), pp. 136-186. Blackwell Science, Oxford.

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