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FIGURE 1-44 Evaluation of the transcriptional activity of mutants of the human glucocorticoid receptor (A), the carboxy-terminal end, and (B) the amino-terminal end of the receptor. The top of each panel shows the intact glucocorticoid receptor with 777 amino acids. Each of the domains is indicated: open box (IMM), the immunogenic region; solid black rectangles, the DNA-binding domain; stipples, the ligand-binding domain. The receptor constructs of panels A and B are prepared via site-directed mutagenesis. In (A), where truncation mutants are evaluated, the numbers with asterisks indicate the last amino acid of the receptor before the COOH-terminal nonsense peptide. In (B), where deletion mutants are evaluated, the numbers indicate amino acids bounding the deletion. These mutant receptors were constructed via standard, but complex,
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Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.