The human pineal gland starts as an evagination of the roof of the third ventricle in the second month of gestation. The pineal anlage, the ependyna, a lobular structure, fuses into a solid and becomes invested with vascular connective tissue, giving a lobular appearance to the pineal parenchyma. The pineal gland then changes from a vertical to a horizontal organ and becomes innervated. In neonates, the pineal is shown to consist of two cell types, type I and type II. Type I cells

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