A,0,T,P AAA A Pregnenolone--Progesterone-DOC -Corticosterone -180H-Corticosterone-»-Aldosterone

j A,O.T,P | A A 170H-Pregnenolone ——170H-Progesterone-11-Deoxycortiso!-Cortisol f © I © ©


FIGURE 2-18 Principal pathways of human steroid hormone synthesis. The details of the enzyme reactions (circled numbers) are summarized in

Table 2-6. Reactions (2), ©, and (8) are found universally in the adrenals, ovary, testes, and placenta. Reactions © and @ are found principally in the testes and ovaries. Reactions (Jl) —> (B) describe the pathway of production from cholesterol of the prohormone vitamin D and its hormonal metabolite products la,25(OH)2D3 and 24,25(OH)2D3. Reaction P450c25 present in the mitochondrial and /or endoplasmic reticulum of the liver. Reactions @ and P450cla and P450c24 present in the mitochondria of the kidney proximal tubule. Tissue codes: A, adrenals; O, ovaries; T, testes; P, placenta; S, skin; L, liver; K, kidney; DHEA, dehydroepiandrosterone (77). [Modified from Miller, W. L. (1988). Molecular biology of steroid hormone biosynthesis. Endocr. Rev. 9, 295-318.]

Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

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