FIGURE 5-22 (A) Cis-active sites in the hGH promoter. Transcription of the GH-1 gene is regulated by proteins that bind to regulatory elements in the 300 bp preceding the start of transcription (arrow). The two Pit-l-binding sites are shown together with sites for NF-1, USF, AP2, Spl, and the glucocorticoid receptor. (B) Pit-1 protein, helices, and domains. The human Pit-1 gene encodes a 291-amino-acid protein that binds to regulatory elements in the GH, PRL, and Pit-1 promoters. It consists of three recognized domains. They are an amino-terminal transcriptional activation domain, a POU-homeo-specific domain containing two «-helices, and a POU-homeodomain containing three a-helices. Reproduced with permission from Parks, J. S., Pfaffle, R. W., Brown, M. R., Abdul-Latif, H„ and Meacham, L. R. (1995). Growth hormone deficiency. In "Molecular Endocrinology" (B. D. Weintraub, ed.), pp. 473-490. Raven Press, NY.

Transcriptional Activation

Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

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