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FIGURE 12-12 Schematic diagram of the relationships of the androgen receptor, chromosomal location, gene, cDNA, and protein. For the receptor protein, the regions of functional domains are indicated. The androgen receptor is known to be phosphorylated on serine 650. Modified with permission from Quigley, C. A. DeBellis, A., Marschke, K. B., El-Awady, M. K., Wilson, E. M„ and French, F. S. (1995). Androgen receptor defects: Historical, clinical and molecular perspectives. Endocr. Rev. 16, 271-321.

TABLE 12-7 Ligand Specificity of the Androgen Receptor

Steroid

Relative competitive index"'1' (%)

Dihydrotestosterone

0 0

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