Cooh

PGI2

FIGURE 16-15 Synthesis of PGI2.

Phospholipids Corticosteroids © I

Endogenous algesic substances

Arachidonic acid Acetylsalicylic acid © I © Bradykinin

Physical stimuli

Mechanical, heat

Prostaglandin E

y sensitize

Afferent fiber

Physical stimuli

Mechanical, heat sensitize

Afferent fiber

itize /

excite directly ^

Nociceptor (produces pain)

itize /

excite directly ^

S X alter microcirculation and vascular permeability u

'Bloocn capillar^

Nociceptor (produces pain)

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