FIGURE 1-25 Protein kinases illustrating the size and location of their catalytic domain. In each case, the catalytic domain (open frame) is about 250 amino acid residues long. The regulatory subunits normally associated with protein kinase A (PKA) and phosphorylase kinase are not shown. Redrawn from Alberts, B„ Bray, D„ Lewis, J., Raff, M., Roberts, K. and Watson, J. D. (1983). "Molecular Biology of the Cell." 2nd ed., p. 707. Garland Publishing, New York.

TABLE 1-4 Hormone-Related Membrane-Spanning Receptors"

Single-membrane-spanning receptor

Without Tyr-PK activity

With Tyr-PK activity

Multiple-membrane-spanning receptors coupled to G protein

Hormone-gated ion channels


Insulin-like growth factors (IGF-1) (IGF-2) Nerve growth factor (NGF)

Growth hormone

Insulin receptor

Platelet-derived growth factor (PDGF-R)

Acetylcholine receptor Parathyroid hormone Calcitonin

Luteinizing hormone (LH)

Human chorionic gonadotropin (HCG) Rhodopsin (the light receptor) Thyrotropin releasing hormone (TRH) receptor y-Aminobutyric acid (GABA)

IP3 receptor (endoplasmic reticulum)

! Note: This is only a partial listing.

TABLE 1-5 Properties of Steroid Receptors
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