Ch2

3 -Hydroxy-3 -methyl-glutaryl-CoA (50)

Cholesterol (3)

Acetyl-CoA +

Acetoacetate ch2oh ch2

h0-c-CH3

Mevalonate (51)

FIGURE 2-13 Biosynthesis of 3-hydroxy-3-methylglutaryl-CoA and indication of its metabolic fate. Six molecules of mevalonic acid are ultimately condensed to create one molecule of squalene.

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