Cd

cholesterol side chain cleavage (see)

Reaction ®

11/3-hydroxyIase

Reactions

aldosterone (11/3,18-hydroxy lase 18-oxidase)

Reaction ®

C-21 hydroxylase

Reactions

17a-hydroxylase/ C-17-C-20-lyase

Reaction ®

estrogen (aromatase)

Adrenals Zona glomerulosa Zona fasciculata Zona reticularis

Testes Sertoli cells Leydig cells Ovary

Glomerulosa Theca

Corpus luteum

" This table describes the organ and cellular distributions of the P450 enzymes concerned with the production of adrenal-, ovary-, and testes-derived steroid hormones. The data are largely derived from in situ hybridization studies employing cDNA probes from molecular biological studies on the indicated P450. The details of the enzyme reactions (circled numbers) are summarized in Table 2-6. Modified from Omara, T. (1994). Proceedings of the IX International Congress on Hormonal Steroids, Dallas, Texas. [Abstract P106]

Tropic Hormone

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