Some experiments performed with isolated, perfused rat pancreas suggest that PGE^ in the micromolar range, can stimulate the release of glucagon and insulin. Since glucagon release precedes that of insulin, the latter may be released secondarily by glucagon rather than in direct response to PGE2. The effective concentrations of PGE2 are in a range close to that observed in extracts of rat pancreas. It seems possible that PGE may be a transducer for several known secretagogues of glucagon.

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