Apical Membrane Iodination Coupling Storage

FIGURE 6-4 Biosynthetic pathway for the production of thyroglobulin. TSH initiates the process via stimulation of the cAMP pathway. The mature mRNA is translated into the 2748-amino acid subunit of 330 kDa. The mature Tg is a dimer of two subunits. Before Tg is secreted, extensive glycosylation occurs. [Modified with permission from Medeiros-Neto, G., Targovnik, H. M., and Vassart, G. (1993). Defective thyroglobulin synthesis and secretion causing goiter and hypothyroidism. Endocr. Rev. 14, 165-183.]

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