FIGURE 7-17 Synopsis of the regulation of expression of the insulin gene. The primary transcription of the insulin gene is selectively stimulated by elevated cAMP and/or glucose. In addition, insulin mRNA levels are stabilized at high glucose levels, which also selectively stimulates the translation of insulin mRNA at the levels of initiation, elongation, and interaction of signal recognition particles (SRP) with a docking protein (DP) [Modified with permission from Steiner, D. F., Bell, G. I., Tager, H. S., and Rubenstein, A. H. (1995). Chemistry and biosynthesis of the islet hormones: Insulin, islet amyloid polypeptide (amylin), glucagon, somatostatin and pancreatic polypeptide. In "Endocrinology" (L. DeGroot, M. Besser, H. G. Burger, J. L. Jameson, D. L. Loriaux, J. C. Marshall, W. D. Odell, J. T. Potts, Jr., and A. H. Rubenstein, eds.), 3rd ed., Vol. 2, Chapter 76, pp. 1296-1328. W.B. Saunders, Philadelphia, PA.]

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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