Patients with acromegaly have reduced amount of adipose tissue mass (63) that normalizes with successful treatment (64). Furthermore, successfully treated patients with acromegaly that normalize their GH secretion demonstrate an increase of predominantly the visceral adipose tissue mass (65). The reverse scenario is seen in adults with hypopituitarism and untreated GH deficiency who have increased amount of body fat mass with abdominal preponderance (57,58), which in response to GH administration results in a profound reduction of visceral adipose tissue and less marked effects on other adipose tissue depots (66). Thus, GH has profound effects on adipose tissue distribution.
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