The Effects of GH Replacement on Body Composition in Adults with GHDeficiency

In all reported studies investigating the effects of GH treatment on body composition, an increase was recorded in average LBM, varying from 2-5.5 kg after six months GH replacement (11-16,20-24). Similar findings have been reported from studies in patients with both adult-onset (AO) and childhood-onset (CO) GH-deficiency (25).

In these studies the changes in LBM were associated with reductions in fat mass of approximately 4-6 kg (11-16,20-24). Similarly this reduction occurs equally in both CO and AO GH-deficiency (25). Anthropometric measurements indicate that the most important change occurs in the abdominal region (10), corresponding to reduced visceral fat mass (16,20).

GH has a potent anti-natiuretic effect, most likely mediated through direct effects of GH and/or IGF-1 on renal tubular sodium absorption, in addition to stimulatory effects on the renin-angiotensin system (26). GH replacement results in an increase in TBW (11,18), particularly in ECW within 3-5 d (26). Plasma volume has been shown to increase after three weeks of GH replacement (17,18) and in a recent study, GH therapy resulted in a 400-mL increase in TBV after three months of treatment (18).

Fire Up Your Core

Fire Up Your Core

If you weaken the center of any freestanding structure it becomes unstable. Eventually, everyday wear-and-tear takes its toll, causing the structure to buckle under pressure. This is exactly what happens when the core muscles are weak – it compromises your body’s ability to support the frame properly. In recent years, there has been a lot of buzz about the importance of a strong core – and there is a valid reason for this. The core is where all of the powerful movements in the body originate – so it can essentially be thought of as your “center of power.”

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