Srif Receptor Subtypes

SRIF induces its biological actions by interacting with membrane-associated receptors. A number of studies had suggested that subtypes of SRIF receptors are expressed in the body (1). Studies on the pancreas suggested that SRIF 28 was much more potent than SRIF in blocking insulin secretion, whereas the peptides had similar potencies in controlling glucagon release (2), indicating that different receptors may be involved in mediating SRIF peptide effects on pancreatic hormone secretions. Receptor binding studies suggested that radiolabeled SRIF analogs bound to multiple sites in different tissue preparations (4). Synthetic peptides such as octreotide and MK 678 bound potently to one site and not the other. Furthermore, one binding site was sensitive to guanine triphosphate (GTP) analogs and Na+ whereas the binding of SRIF to the other site was not. In addition, antibodies made against native SRIF receptors revealed heterogeneities in the size of SRIF receptors, which are likely to be owing to the antibodies being raised against different receptor subtypes (5).

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