Protein Metabolism

A small number of studies have assessed protein metabolism in GH-deficiency. These have employed stable isotope tracer techniques, and have demonstrated reduced protein flux and synthesis in adults with GH-deficiency compared with normal matched controls (11,48). GH replacement results in considerable increases in protein synthesis in the short term (1-2 mo [11,48]), with a return to baseline rates after six months (11), most likely as a result of achieving a new baseline rate of metabolism.

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