Pharmacokinetics

A precise bioavailability figure for L-163,191 (44) in dogs was not possible owing to nonlinear kinetics, however, it is estimated to be >60% (54,61). In rats the oral bioavailability was dose dependent in the range 6-22% and the terminal half-life was a relatively short 1.8 h at an iv dose of 0.5 mg/kg (61). However, the rate of elimination of L-163,191 was much slower in dogs and its volume of distribution was lower resulting in a terminal half-life of between 4-6 h in this species.

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