Mathematical Models

A variety of computer software programs that detect discrete GH peaks, including Pulsar, Ultra, Detect and Cluster analysis, have allowed further refinement of the pulsatile pattern of GH release. Deconvolution analysis overcomes some of the inherent limitations of defining the pulsatile nature of GH hormone secretion by attempting to remove the impact of hormone clearance kinetics on plasma hormone concentrations, thereby exposing the underlying secretory profile (115,116). This mathematical model allows the calculation of hormone pulse amplitude (maximal secretion rate), pulse duration, subject-specific metabolic clearance rates, hormone half-life, the presence and magnitude of any basal ("tonic") hormone secretion, and the number and temporal location of all significant secretory bursts (115). Time series analysis has also been used to characterize GH pulsatility (117-119).

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