M

Magnetic resonance imaging (MRI)

hypopituitarism, 195 McCune Albright syndrome, 204 Memory hippocampal GHR, 155 Men sleep periods

GH profiles, 262f

Menopausal women

GH administration and calcitonin, 241,242 Metabolic Syndrome, 247 Metabolism

GHD, 226, 227 Micropenis, 205 MK-0677, 2, 319, 320, 325, 326 animal evaluation, 57, 58 cell culture studies, 59 childhood onset GHD, 11 clinic, 58 compound 44

discovery, 57 diet-induced nitrogen wasting, 11 discovery, 52-58 vs. GH, 10, 11 as GHRP-6 mimetic, 59-62 ceil culture studies, 59 receptor cloning and mutagenesis, 60

rcceptor studies, 59 tripeptide analogs, 60-62 reccptor, 26

structure-activity studies, 52—57 Molecular defects

GH axis, 169-183 Molecular effects

GH, 234, 235 Molecular mechanisms

GH axis, 171-182 Molecular ontogeny pituitary gland, 173 MSG

GHRH deficiency, 171 Multiple GH family gene deletions, 177 Multiple GH secretagogue receptors physiological evidence, 90, 91 Multiple GH secretagogue receptor subtypes physiological evidence, 90, 91 Multiple pituitary hormone deficiencies classification system, 175t Muscle function

GH, 9 Muscle strength GHD, 225

Muscle wasting

GHS, 326 Mutational analysis hGHR/HG interaction, 137-139 Mutations GHD, 179 GH gene, 178 GHR

defects, 180, 181 domains, 181t GHRH receptor, 174 hypothalamus, 171 IGF-1 deficiency, 181, 182 pituitary transcription factor, 174-176 Myocardial infarction noninsulin dependent diabetes, 9

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