Lipid and Lipoprotein Metabolism

Consistently studies have demonstrated that adults with GH-deficiency have elevated concentrations of total cholesterol, low density lipoprotein-cholesterol (LDL-C) and apolipoprotein B (ApoB) compared with an age and sex matched control population or the predicted range (25,53,54). Characteristically, high density lipoprotein-cholesterol (HDL-C) is reduced and triglyceride (TG) concentrations are elevated compared with healthy controls (55). Therefore GH-deficiency is associated with a lipid profile recognized to be associated with premature atherosclerosis and cardiovascular disease.

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