The growth hormone releasing peptides (GHRPs), in contrast to growth hormone releasing hormone (GHRH), were invented rather than discovered. "Reverse pharmacology," a term recently proposed by Michael Conn, was suggested to designate the developmental GHRP process (1). GHRPs and their mimetics will undoubtedly have a clinical role in the future. Two immediate future objectives of salient importance will be isolation and identification of the putative native hormone for which GHRPs are mimetics and elucidation of its role in the physiological secretion of GH. Moreover, whether this hormone is involved in the pathophysiology of GH deficiency in children and adults is still to be determined.
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