Insulin Resistance

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Insulin resistance is a common condition and can be seen, for example, in NIDDM, obesity, and hypertension. The inter-relationship between insulin resistance and these conditions, as well as the exact mechanisms for insulin resistance, have not yet been fully clarified. It has recently been clear that GH-deficient adults are also insulin resistant in peripheral tissues (as measured using the hyperinsulinemic euglycemic clamp technique [67,68]). In our study, glucose disposal rate (GDR) in the GH-deficient group was less than half that of controls, when calculated according to body weight and when corrected for body fat (67). The decreased lean body mass and the increased abdominal obesity in GH deficiency may be of importance for this finding as the association between increased body fat mass and insulin resistance is stronger in the presence of abdominal obesity (69). Low levels of serum IGF-1 may also contribute to insulin resistance (70) as IGF-1 stimulates the glucose transport in skeletal muscle (71). Other factors such as different composition in skeletal muscle fibers (72) and decreased physical activity in adults with GH deficiency may be of importance.

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