CLOCK TIME CLOCK TIME
Fig. 3. Mean (± SD) plasma levels of GH during the continuous intravenous infusion of saline (left) or of GHRH, 1 ^g/Kg/h (right), for 24 h in 6 healthy young men. Infusions were preceded and followed by bolus injections of GHRH, 1 ^g/Kg iv. There is an increase in GH secretion during GHRH infusions, but in an episodic pattern, with periods of higher GH occurring at approximately the same time as during saline infusions. The response to GHRH injections is unaltered following saline infusions but decreased after GHRH infusions, showing attenuation of the response or depletion of releasable GH stores. From ref. 9.
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