Index

Abdominal obesity GH secretion, 249, 250 GH treatment, 252-255 Acquired growth hormone deficiency (GHD) causes, 206t Acromegalic patients, 273 Acromegaly, 250,299-301

GHRP-6, 32 Acute lymphoblastic leukemia (ALL), 196, 197 spontaneous pulsatile growth hormone secretion, 198f Adipose tissue, 248, 249 GH, 9

Adolescents. See Pediatrics Adrenocorticotropic hormone (ACTH)

GHS pattern, 318, 319 Adult-onset GHD, 306,307 GH administration, 239, 240 osteoporosis, 235, 236 Adults childhood-onset GHD

osteoporosis, 235 GH administration, 241, 242

childhood-onset GHD, 237, 238 GHD, 221-229

body composition, 223, 224 bone mineral density and bone metabolism, 224 cardiovascular system, 224, 225 exercise and strength, 225 GHS, 324

metabolism, 226, 227 quality of life, 222, 223 Syndrome X. 250-252 GHRP-2, 33-38 GHS-R ligands, 10, 11

rhGH, 46 sleep

GH secretion, 261, 262 sleep periods

GH profiles, 262f African sleeping sickness, 272 Aged. See also Adults; Eideriy GHRH treatment, 306-310 GHS, 324-326

sleep-related GH secretion, 270 siow-wave sleep, 271 f Age-related. See also Adults osteoporosis GHD, 236, 237 Agonists calcium fluctuations, 129 AIDS GH, 285-293 rhGH, 46 Alanine-scanning mutagenesis hGHR/HG interaction, 137-139 Alpha-helically-stabilized GHRH analogs, 103-105 Altitude

GH secretion, 199 Ames dwarfism

PROP-1 (prophet of pit-1), 175 191-amino acid peptide. See Pituitary

GH Amino acids benzolactam secretagogues, 52 GH secretion, 193 Animal evaluation orally active MfC-0677, 57, 58 Anorexia nervosa

GH secretion, 194 Antisensc oligonucleotides, 157 Arcuate cell identification GH secretagogue, 86—89

Arcuate nucleus activation

GH secretagogue, 86 fos-like immunorcactive, 87f GHRP-6, 86 Arginine

GH adequacy testing procedures, 182, 183

GH response, I96f Aromatic amino acid variations, 56t Atherosclerosis, 224 Atropine, 193

Autosomal dominant manner

Pit-1 deficiencies, 175 Autosomal recessive inheritance

GHAD, 178 Auxological evaluation

GH-IGF axis, 183 Awakenings

GH secretion, 268

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