H

Height velocities

GHRH treatment, 305f HESX1. See Rpx (Rathke pouch homeobox) High-affinity GH binding protein (HA-

GHBP), 195 High-Ala content analogs, 103 High altitude

GH secretion, 199 Hippocampal Gi !R

learning and memory, 155 HisD2MeTrpAlaTipDPheLysNh2,25 i listologic effects

GH, 234, 235 HIV. See Human immunodeficiency virus (HIV) Hormonal regulation

GH secretion, 199-204 Hormone exocytosis calcium, 129

Human growth hormone (hGH). See also Growth hormone (GH) overview of, i—11 structure, 132 Human growth hormone receptor

(hGHR). See ¿dso Growth hormone receptor (GHR) activation, 131-141 CNS, 146, 147 cytoplasmic region, 139 extracellular domain structure, 132-134 HG binding transmembrane signaling, 134—137 HG complex intracellular following, 139, 140 HG interaction alanine-scanning mutagenesis,

137-139 mutational analysis, 137—139 Human immunodeficiency virus (HIV), 285

GH and IGF-1, 287 GH therapy, 287-289 IGF-1, 290

IGF-1 and GH therapy, 290. 291 weight loss, 286 Human placental lactogen. See Chorionic somatomammotropin, human (hCS)

Hyperbilirubinemia, 205 Hyperthyroid, 200 Hyperthyroidism

GHS, 328 Hypogammaglobulinemia, 179 Hyponatremia, 205 Hypopituitarism, 204—207

magnetic resonance imaging (MRI), ~ 195 Hypothalamic effects cranial irradiation, 195 Hypothalamic lesions GH secretion, 195 Hypothalamic peptides, 171 Hypothalamic-pituitary-adrenal (HPA) axis

Syndrome X, 249

1 lypothaiamic-pituitary disconnection

GHRP-6, 32 Hypothalamic testing, 207t Hypothalamus, 171 Hypothalamus vs. pituitary

GHRP, 22 Hypothyroidism GH deficiency, 204

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