The relatively isolated position of the GHS-R in the dendrogram suggests that GPC-Rs may exist that constitute closely related GHS-R family members. Their isolation and functional analysis may shed light on the relevance of the relationship between the GHS-R and the neurotensin receptor (NT-R). Targeted disruption of the GHS-R will hopefully aid in defining the normal physiological role of the GHS-R. Finally, the identification of the natural ligand for the GHS-R will allow the dissection of the molecular mechanisms by which this receptor and its ligand participate in the control of pulsatile GH release in humans and it will further facilitate the assessment of the clinical role of the GHSs in human and animal health.
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