Fasting

Fasting enhances pulsatile GH release in normal adult subjects (22). GH secretion in healthy subjects following a 32-56 h fast increased fivefold in the 24-h endogenous GH production rate compared to subjects on a controlled diet, and twofold in the number of GH secretory bursts and mass of GH secreted per burst. Insulin-like growth factor 1 (IGF-1) concentrations were unchanged. Thus, starvation-induced increases in GH secretion appear to be mediated by the effects of increased GHRH release or reduced SRIF tone (22). Similar results are expected in children.

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