The frequency of sleep disorders increases markedly with aging. It has long been known that nocturnal secretion of GH is correlated with episodes of slow-wave (delta) sleep (SWS); but it is not clear whether this means only that SWS stimulates GH secretion, or whether the stimuli to GH secretion, such as GHRH, can also stimulate SWS. Kerkhofs and colleagues reported that GHRH could acutely promote sleep in normal men, with the specific effects depending upon the timing of drug administration (51). This topic is reviewed by Van Cauter and colleagues in this volume (Chapter 15).
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