Effects of Somatostatin on Sleep

Inconsistent data have been reported concerning the action of somatostatin on sleep. In the rodent, REM sleep was inhibited by immunoneutralization of endogenous soma-tostatin (111) and enhanced by intracerebroventricular administration of exogenous somatostatin (112), while non-REM sleep was inhibited by subcutaneous injections of a long-acting somatostatin analog (113). In humans, repeated intravenous injections or infusion of somatostatin did not influence sleep quality in normal young subjects (107,114), but REM sleep was decreased by somatostatin in the elderly (115).

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