Effects of Manipulations of the Sleep Wake Cycle

Fig. 2. Upper panel: Mean (+SEM) profiles of plasma GH in 8 normal young men studied during a 53-h period including 8 h of nocturnal sleep, 28 h of sleep deprivation and 8 h of daytime sleep. The black bar represents the nocturnal sleep period. The open bar represents the period of nocturnal sleep deprivation. The dashed bar represents the period of daytime sleep. Lower panel, Individual plasma GH profile from one representative subject. Symbols are as in upper panel.

Fig. 2. Upper panel: Mean (+SEM) profiles of plasma GH in 8 normal young men studied during a 53-h period including 8 h of nocturnal sleep, 28 h of sleep deprivation and 8 h of daytime sleep. The black bar represents the nocturnal sleep period. The open bar represents the period of nocturnal sleep deprivation. The dashed bar represents the period of daytime sleep. Lower panel, Individual plasma GH profile from one representative subject. Symbols are as in upper panel.

demonstrated an increase of GH levels following the re-initiation of sleep (25). Finally, a study of night workers indicated that the main GH secretory episode still occurred during the first half of the daytime sleep period (15).

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