Contributors

Mark A. Bach, md, phd, Division of Clinical Research Endocrinology and Metabolism,

Merck & Co., Rahway, NJ Howard B. A. Baum, md, Dallas Diabetes and Endocrine Center, Dallas, TX Bengt-Ake Bengtsson, md, phd, Research Center for Endocrinology and Metabolism,

Sahlgrenska University Hospital,Sahlgrenska, Göteborg, Sweden Pamela A. Bennett, bsc, dphil, Division of Neurophysiology, National Institute for Medical Research, London, UK Barry Bercu, md, Division of Pediatric Endocrinology, Diabetes, and Metabolism, Department of Pediatrics and Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, FL; Department of Endocrinology, All Children's Hospital, St. Petersburg, FL C. Y. Bowers, md, Endocrinology and Metabolism Section, School of Medicine, Tulane

University Medical Center, New Orleans, LA David Brown, msc, Laboratory of Computational Neuroscience, The Babraham

Institute, Cambridge, UK Paul V. Carroll, Department of Endocrinology, St. Bartholomew's Hospital, London, UK

Fernando Cassorla, md, Institute of Maternal and Child Research, Department of Pediatrics, University of Chile, Santiago, Chile Emanuel R. Christ, Department of Endocrinology and Diabetology, University

Hospital of Geneva, Geneva, Switzerland Georges Copinschi, md, phd, Centre d'Etudes des Rythmes Biologiques (CERB) and Laboratory of Experimental Medicine, Université Libre de Bruxelles, Brussels, Belgium

David H. Coy, phd, Peptide Research Section, Department of Medicine, School of Medicine, Tulane University Medical Center, New Orleans, LA Suzanne L. Dickson, phd, Department of Physiology, University of Cambridge,

Cambridge, UK; Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Sahlgrenska, Göteborg, Sweden Linda Anne DiMeglio, md, Section of Pediatric Endocrinology and Diabetology and the Herman B. Wells Center for Pediatric Research, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN

Scott D. Feighner, phd, Department of Biochemistry and Physiology, Merck & Co., Rahway, NJ

Glenn J. Gormley, md, phd, Division of Clinical Development, Merck & Co., Horsham, PA

Howard J. Heinze, md, Section of Pediatric Endocrinology, Department of Pediatrics,

University of South Carolina School of Medicine, Columbia, SC Paul L. Hofman, mbchb, Section of Pediatric Endocrinology and Diabetology and the Herman B. Wells Center for Pediatric Research, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN

Andrew D. Howard, phd, Department of Metabolic Disorders, Merck & Co., Rahway, NJ

Gudmundur Johannsson, md, phd, Research Center for Endocrinology and Metabolism,

Sahlgrenska University Hospital, Sahlgrenska, Göteborg, Sweden Jan-Ove Johansson, md, phd, Research Center for Endocrinology and Metabolism,

Sahlgrenska University Hospital, Sahlgrenska, Göteborg, Sweden Anne Klibanski, md, Neuroendocrine Unit, Department of Medicine, Massachusetts

General Hospital, Boston, MA Gareth Leng, phd, Department of Physiology, University of Edinburgh, Edinburgh, UK

George Liapakis, phd, Department of Pharmacology, University of Pennsylvania

School of Medicine, Philadelphia, PA Per Märin, md, phd, Department of Heart and Lung Diseases, Sahlgrenska University

Hospital, Sahlgrenska, Göteborg, Sweden George R. Merriam, md, VA Puget Sound Health Care System and Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA

Kathleen Mulligan, phd, Division of Endocrinology, San Francisco General

Hospital, San Francisco, CA Arthur A. Patchett, phd, ??, Merck & Co., Rahway, NJ Kenneth H. Pearce, phd, Department of Molecular Sciences, GlaxoWellcome

Research and Development, Research Triangle Park, NC Ora Hirsch Pescovitz, md, Section of Pediatric Endocrinology and Diabetology and the Herman B. Wells Center for Pediatric Research, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, IN Terry Reisine, phd, Convergence Ventures, Los Angeles, CA Iain C. A. F. Robinson, ma, dphil, Division of Neurophysiology, National Institute for Medical Research, London, UK Morris Schambelan, md, Department of Medicine, University of California at San

Francisco, San Francisco, CA Gurkeerat Singh, phd, Center for Cancer Pharmacology, University of Pennsylvania

School of Medicine, Philadelphia, PA Roy G. Smith, phd, Huffington Center on Aging and Department of Cell Biology,

Baylor College of Medicine, Houston, TX Peter Sönksen, Division of Medicine, St. Thomas Hospital Medical School, London, UK

Elinor A. Stephens, phd, Laboratory of Computational Neuroscience, The Babraham

Institute, Cambridge, UK Michael O. Thorner, phd, Department of Medicine, University of Virginia Health

Sciences Center, Charlottesville, VA Eve Van Cauter, phd, Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, IL Lex H. T. Van der Ploeg, phd, Department of Biochemistry and Physiology, Merck

& Co., Rahway, NJ James A. Wells, phd, Sunesis Pharmaceuticals, Inc., Redwood City, CA Matthew J Wyvratt, phd, ??, Merck & Co., Rahway, NJ

Overview of Human Growth Hormone

Research and Clinical Practice

Roy G. Smith, PhD

Contents

Introduction

The Roles of GHRH, SST, and GHS-R

in Regulating GH Release Developments in Basic Science of GH Clinical Applications of GH Replacement References

Diabetes Sustenance

Diabetes Sustenance

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