The regulation of growth by elements of the GH axis is a complex process that we have only begun to understand. We are currently in an exciting era of basic and clinical investigations of growth hormone axis defects. Further evaluation of the genes and physiology involved in the production, secretion, and actions of GH will continue to clarify the molecular basis of other growth hormone axis defects. This, in turn, may allow us to target new diagnostic and therapeutic strategies for affected patients.

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