C

Calcitonin menopausal women, 241, 242 Calcium hormone exocytosis, 129 Calcium fluctuations agonists, 129 Caloric supplementation, 286, 287 CAMP, 171 Camphorsulfonamide discovery of, 50, 51 GHS

structure of, 50f structure-activity relationships, 5If

Carbohydrate metabolism

GHD. 226 Cardiac systolic function

GHD, 225 Cardiovascular sysiem

GHD, 224. 225 Carpal tunnel compression

GH replacement, 227 Catabolic states

GHS, 326,327 Catecholamine regulation lipolytic process, 248 Cell culture studies

MK-0677 as GHRP-6 mimetic, 59 Cellular effects GH, 234, 235 Central nervous system (CNS), 145—160 experimental approaches, 156, 157 GH access, 152, 153 GH feedback, 153-155 GH/GHR autoregulation, 150, 151 GH physiological effects, 153 gonadal steroids, 151, 152 hGHR, 146, 147 hGHR expression, 147, 148

developmental regulation, 148-150 transgenic models, 157-159 Cerebral side effects

GH replacement, 227 Cerebral spinal fluid, GH and, 152 Chemotherapy, rhGH and, 46 Childhood-onset GHD MK-0677, 11 osteoporosis, 235 Children. See also Pediatrics

GH deficiency, 8, 9 Cholecystokinin (CCK)-A antagonists,

50,51 Cholesterol

GH replacement, 227 reduction, 253, 254 Syndrome X and GHD, 251 Cholinesterase inhibitors obesity, 199 Chorionic somatomammotropin, human (hCS), 173, 174, 191 deficiency, 177

Chorionic somatomammotropin (CS), 173 Chromosomal mutations

GHD, 179 Chronic corticosteroid exposure

GHS, 327,328 Circadian modulation

GH secretion, 263, 264 Clone 7-3

nucleotide structure, 74 Clonidine

GH adequacy testing procedures, 182, 183

Cluster analysis

GH peak detection program, 208 Codon 271, 175, 176 Compound 25, 53 Compound 44 discovery, 57 safety assessment, 58 Congenital growth hormone deficiency (GHD) causes, 206t Corticosteroid exposure

GHS, 327, 328 Corticosteroid therapy

GH secretion, 201, 202 Coriicotrophin releasing hormone

(CRH), 249 Cortisol, 249 Cortistatin, 1 iO Countries

GHD, 176 Cranial irradiation

GH secretion, 195-199 GH secretion pattern, I97f Cultures, GHD and, 176 Cushing's syndrome GHRP-6, 32 GHS, 328 GH secretion, 201

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