Acknowledgments

The authors thank Jennifer Anderson, Michael Chou, Doris Cully, Carmen Diaz, Mike Dashkevicz, Alex Elbrecht, Michael Hamelin, Donna Hreniuk, Karen Kulju McKee, Paul Liberator, Oksana Palyha, Philip Paress, Charles Rosenblum, Xiao-Ming Guan, Carina Tan (Genetics and Molecular Biology); Bret Defranco, Keith Judd, Eve Szekely, Don Thompson (Branchburg Farms); Joe Arena, Lee Chaung, Ken Liu, Anna Pomes, Sheng-Shung Pong, Jim Schaeffer (Cell Biology and Physiology); Dennis Dean, Dave Melillo (Drug Metabolism); Ravi Nargund, Art Patchett (Exploratory Chemistry); Patrick Griffin and Traci Clark (Analytical Biochemistry); Julie DeMartino (Inflammatory Research); Robert Havens, Mike Rigby, Dalip Sirinathsinghji-(Terlings Park

Fig. 8. Dendrogram alignment of the GHS-R and other GPC-Rs. Database searches (Genbank 92, EMBL 43, Swiss-Prot 31, PIR 45, dEST [GBest 92], Prosite 12), sequence alignments and analysis of the GHS-R nucleotide, and protein sequences were carried out using the GCG Sequence Analysis Software Package (Madison, WI; PileUp, peptide structure and motif programs). The amino acid sequence of representative members (56 sequences) for all known classes (Families I—IV and pheromone) of GPC-Rs were used to construct the dendrogram using the clustal method (PAM-250, gap and length penalty =10).

Fig. 8. Dendrogram alignment of the GHS-R and other GPC-Rs. Database searches (Genbank 92, EMBL 43, Swiss-Prot 31, PIR 45, dEST [GBest 92], Prosite 12), sequence alignments and analysis of the GHS-R nucleotide, and protein sequences were carried out using the GCG Sequence Analysis Software Package (Madison, WI; PileUp, peptide structure and motif programs). The amino acid sequence of representative members (56 sequences) for all known classes (Families I—IV and pheromone) of GPC-Rs were used to construct the dendrogram using the clustal method (PAM-250, gap and length penalty =10).

Neurosciences center); Kristine Prendergrast, Dennis Underwood (Molecular Design); Michael S. Phillips (Human Genetics); Molecular Cell Science Inc., Gwen Childs (University of Texas); Keith Elliston (Bioinformatics); and Sunil Gupta (Cellular & Molecular Biology) for their participation and invaluable input into the GHS-R program.

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