Effects of Somatostatin on Sleep

Inconsistent data have been reported concerning the action of somatostatin on sleep. In the rodent, REM sleep was inhibited by immunoneutralization of endogenous soma-tostatin (111) and enhanced by intracerebroventricular administration of exogenous somatostatin (112), while non-REM sleep was inhibited by subcutaneous injections of a long-acting somatostatin analog (113). In humans, repeated intravenous injections or infusion of somatostatin did not influence sleep quality in normal young...

Gh Treatment Of Patients With Abdominal Obesity

As GH promotes lipolysis low levels of GH has therefore been suggested to be of importance for the maintenance of the obese condition. The calorigenic effects of GH in obese subjects has also been known for many years (99). Some trials have therefore addressed the question of whether GH administration through its calorigenic and lipolytic action might enhance weight loss during dietary restriction in obese subjects. Both short-term (100) and several weeks of GH treatment (101,102) in...

References

Beck JC, McGarry EE, Dyrenfurth I, Venning EH. Metabolic effects of human and monkey growth hormone in man. Science 1957 125 884,885. 2. Raben MS. Treatment of a pituitary dwarf with human growth hormone. J Clin Endocrinol Metab 1958 18 901-903. 3. Isaksson OGP, Lindahl A, Nilsson A, Isgaard J. Mechanism of stimulatory effect of growth hormone on longitudinal bone growth. Endocr Rev 1987 8 426-438. 4. Eden S, Isaksson OGP, Madsen K, Friberg U. Specific binding of growth hormone to isolated...

Long vs Short Acting Compounds GH Secretory Pattern and Hormonal Specificity

In clinical studies, single doses of growth hormone secretagogues, given intravenously, intranasally, or orally have resulted in a dramatic elevation in serum GH levels (to approx 40-70 ng mL) (38-45) accompanied by modest post-dose increases in serum cortisol (mediated by ACTH) and prolactin (46,47). Since growth hormone and prolactin secreting cells are derived from the same embryonic lineage, stimulation of prolactin can Fig. 3. Serum samples were collected every 10 min from each of three...

Neurosecretory Dysfunction

The clinical evaluation of infants, children, and adolescents with growth disorders may include provocative tests of GH secretion and 24-h profiles of spontaneous GH release however, there is currently no gold standard laboratory test for the diagnosis of GH deficiency (121,122). A blunted GH response to known GH secretogogues may help to identify subjects suspected to be GH-deficient in the clinical setting of growth retardation (< 3rd percentile), diminished growth velocity, and delayed...

Discovery Of The Benzolactam Secretagogues

With the renewed interest in potential clinical applications of GH, Merck researchers in 1988 became interested in discovering an orally active nonpeptidyl mimic peptidomimetic of GHRP-6. Extensive structure-activity relationships for GHRP-6 had already been published 5,8,9 . Aromatic residues were favored at positions 2, 4, and 5 and a basic amino terminus was important for GH releasing activity. In addition, preliminary evidence at Merck suggested that the GHRP-6 receptor hereafter referred...