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W.G. Jiang et al. (eds.), Growth Factors and their Receptors in Cancer Metastasis, 79-91. © 2001 Kluwer Academic Publishers. Printed in the Netherlands.

recently, specific immunomodulatory genes, such as interleukin-12 (IL-12), have been tested using adenoviral vector-mediated in situ and gene-modified cell based vaccine protocols. The results of these preclinical studies are promising and demonstrate the possibility of effectively generating cytotoxic activities in localized prostate cancers through the recruitment of activated immunocytes while generating systemic anti-tumour immunity that results in antimetastatic activities. We discuss the potential of IL-12 gene therapy for prostate cancer in this review.

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10 Ways To Fight Off Cancer

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