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Copyright © 2006 by John Wiley & Sons, Inc. All rights reserved.

Published by John Wiley & Sons, Inc., Hoboken, New Jersey. Published simultaneously in Canada.

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Library of Congress Cataloging-in-Publication Data:

Glycogen synthase kinase 3 (GSK-3) and its inhibitors : drug discovery and development / [edited by] Ana Martinez, Ana Castro, Miguel Medina.

p. cm. - (Wiley series in drug discovery and development) Includes index.

ISBN-13: 978-0-471-77001-5 (cloth) ISBN-10: 0-471-77001-9 (cloth)

1. Glycogen synthase kinase-3. 2. Glycogen synthase kinase-3 - Inhibitors. I. Martinez, Ana, 1961- . II. Castro, Ana. III. Medina, Miguel, 1959- . IV. Series.

[DNLM: 1. Protein Kinase Inhibitors-therapeutic use. 2. Glycogen Synthase Kinase 3-antagonists & inhibitors. 3. Glycogen Synthase Kinase 3-physiology. QU 143 G568 2006] QP606.P76G59 2006

572'.567-dc22 2006007195

Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1

To our families and co-workers that hold and help us in our research

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